Injection:

• 500 mg/5 mL (100 mg/mL) solution in a single- dose vial

• 200 mg/2 mL (100 mg/mL) solution in a single- dose vial

– Confirm the presence of amyloid beta pathology prior to initiating treatment.

– The recommended dosage is 10 mg/kg which must be diluted and then administered as an intravenous infusion over approximately one hour, once every two weeks. (2.2)

– Obtain a recent (within one year) brain MRI prior to initiating treatment to evaluate for pre- existing Amyloid Related Imaging Abnormalities (ARIA). (2.3, 5.1)

– Obtain an MRI prior to the 5th, 7th, and 14th

infusions. If radiographically observed ARIA

occurs, treatment recommendations are based on

the type, severity, and presence of symptoms.

(2.3, 5.1)

– Dilution in 250 mL of 0.9% Sodium Chloride Injection, USP, is required prior to administration. (2.4)

– Administer as an intravenous infusion over approximately one hour via a terminal low- protein binding 0.2-micron in-line filter. Best Place to Buy Leqembi (lecanemab) Online without Prescription.

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Amyloid-Related Imaging Abnormalities Monoclonal antibodies directed against aggregated forms of beta-amyloid, including LEQEMBI, can cause amyloid-related imaging abnormalities (ARIA), characterized as ARIA with edema (ARIA-E), which can be 5 observed on MRI as brain edema or sulcal effusions, and ARIA with hemosiderin deposition (ARIA-H), which includes microhemorrhage and superficial siderosis. (Buy Leqembi online)  ARIA- H can occur spontaneously in patients with Alzheimer’s disease. ARIA-H associated with monoclonal antibodies directed against aggregated forms of beta-amyloid generally occurs in association with an occurrence of ARIA- E. ARIA-H of any cause and ARIA-E can occur together. ARIA is usually asymptomatic, although serious and life-threatening events, including seizure and status epilepticus, rarely can occur. When present, reported symptoms associated with ARIA may include headache, confusion, visual changes, dizziness, nausea, and gait difficulty. Focal neurologic deficits may also occur.

Symptoms associated with ARIA usually resolve over time. Buy Leqembi (lecanemab-irmb) Online without prescription